Adni Data Use Agreement

The continuous, long-term collection of varied and expanding longitudinal data has led to a heterogeneous, complex and significant accumulation of data. Since the first ADNI phase (ADNI 1), different cohorts of studies (healthy control, mild cognitive impairment (MCI) and patients with Alzheimer`s disease (AD) have been followed by different protocols. Some subjects undercame FDG-PET scans, some of which also had Pittsburgh Compound B PET scanners; One subgroup of subjects had magnetic resonance (MR) scans performed on both 1.5 and 3T scanners, while others had only 1.5T scanners. During subsequent ADNI phases (ADNI GO and ADNI 2), additional cohorts were added for Early AEFi (EMCI), Late MCI (LMCI) and Significant Memory Problems (MMC) and added new clinical assessments [7], AV45 PET scanners replace Pittsburgh Compound B PET scans [8] and additional specific MR scan sequences were added [9-10]. Genome-wide association analysis data (GWAS) containing illumina Human610-Quad and Illumina HumanOmniExpress Chipsets (Illumina, Inc. San Diego (CA) was added for ADNI subgroups 1 and ADNI GO/2 respectively in 2009 and 2012, and last year, total genome sequencing of 818 subjects was completed. Throughout the study, image and biospekte analysts reported results at different times and for different subgroups of subjects. All of these changes and additions to studies have contributed to an increasingly valuable but different data set. The infrastructure should provide flexible methods for describing data and relationships between different metadata characteristics (e.g.B. In 2012, the Alzheimer Association and the Brin-Wojcicki Foundation provided funding for the whole genome sequencing (WGS) of 818 adni. The resulting amount of genetic data, nearly 200 terabytes, exceeds the capacity to deploy on the Internet. The SNPs and Indels data resulting from this effort can be downloaded from the ADNI repository, but WGS researchers interested in large genetic files should request data via an online application form containing information about the production of the WGS data and describing how the data is received on hard drives…

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